Contichrom CUBE is a chromatographic purification system that enables a quantum leap in purification efficiency by using a unique continuous purification process with two columns, and a new generation of continuous purification process that can be used for various types of chromatographic purification such as ion exchange and reversed phase, not only affinity. Compared to batch purification with a single column, this system enables purification with high purity and high yield in a short period of time at a low cost, resulting in a quantum leap in productivity.